3-Substituted-5-hydroxy(mercapto)alkylidene-rhodanine derivative

Details 3-Substituted-5-hydroxy(mercapto)alkylidene-rhodanine derivative 3-Substituted-5-hydroxy(mercapto)alkylidene-rhodanine derivative

1975-03-14

1976-06-29

Drezin, Norman A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424270, A61K 3144, A61K 31425

Patent

active

039669424

ABSTRACT:
3-Substituted-5-hydroxy(mercapto)alkylidene-rhodanine derivatives in which the 3-substituent is lower alkyl, cycloalkyl, alkenyl, phenyl, phenylalkyl, substituted phenyl or pyridylmethyl and having anti-arthritic activity are generally prepared from the appropriate 5-unsubstituted rhodanine by reaction with an orthoester followed by alkaline hydrolysis of the intermediate 5-alkoxyalkylidene rhodanine to give the 5-hydroxyalkylidene products or treatment of the intermediate rhodanine derivative with sodium sulfide to give the 5-mercaptoalkylidene products.

REFERENCES:
patent: 2658890 (1953-11-01), Croxall
patent: 2713579 (1955-07-01), Knott
patent: 2739970 (1956-03-01), Knott
patent: 2839404 (1958-06-01), Knott
Behringer et al., Berichte, 91, 2773-2783 (1958).
Lo et al., J. Amer. Chem. Soc., 76, 4166-4169 (1954).
Knott, J. Chem. Soc. (1954), 1482-1490.

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