3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S421000, C548S484000

Reexamination Certificate

active

07629376

ABSTRACT:
The present invention discloses and claims compounds of formula (I) and formula (II)as inhibitors of human casein kinase Iε, and methods of using the compounds of formula (I) and formula (II) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. The R-group substituents are defined herein and pharmaceutical compositions comprising compounds of formula (I) or formula (II) are also disclosed and claimed.

REFERENCES:
patent: WO 94/14851 (1994-02-01), None
patent: WO 2005/061498 (2005-07-01), None
Ning, K., et. al., Circadian Regulation of GABAA Receptor Function by CKI-Epsilon-CKI-delta in the rat Suprachiasmatic Nuclei, Nature Neuroscience, Nature American, vol. 7, No. 5, (2004).

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