3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid...

Details 3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid... 3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid...

2011-04-12

2011-04-12

McKane, Joseph (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S414000

Reexamination Certificate

active

07923466

ABSTRACT:
Methods for the treatment of a patient suffering from a disease or disorder ameliorated by inhibition of casein kinase Iε activity comprising the administration of a compounds of formula (I) and formula (II)as inhibitors of human casein kinase Iε, and methods of using the compounds of formula (I) and formula (II) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. The R-group substituents are defined herein and pharmaceutical compositions comprising compounds of formula (I) or formula (II) useful in the claimed methods of treatment are also disclosed.

REFERENCES:
patent: WO 94/14851 (1994-02-01), None
patent: WO 2004/014851 (2004-02-01), None
patent: WO 2005/061498 (2005-07-01), None
Takano et al. Neuropsychopharmacology 2004, 29, 1901-09.
Veenstra-VanderWeele et al. Neuropsychopharmacology 2006, 31, 1056-63.
Schafer et al. (Drug Discovery Today 2008, 13 (21/22), 913-916).
Horig et al. Journal of Translational Medicine 2004, 2(44).
Ning, K., et. al., Circadian Regulation of GABAA Receptor Function by CKI-Epsilon-CKI-delta in the rat Suprachiasmatic Nuclei, Nature Neuroscience, Nature America, vol. 7, No. 5, (2004).

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