3-substituted-3-(substitutedsulfonyl or sulfanyl)...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

06949661

ABSTRACT:
The invention relates to compounds of Formula (I), to processes for their preparation and pharmaceutical compositions thereof, that inhibit the Ras farnesyl-protein transferase enzyme (FPTase), and may be used as an alternative to, or in conjunction with, traditional cancer therapy for the treatment of ras oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid.

REFERENCES:
patent: WO 95/24400 (1995-09-01), None
patent: WO 97/36605 (1997-10-01), None
patent: WO 98/07692 (1998-02-01), None
patent: WO 99/05117 (1999-02-01), None
patent: WO 01/85685 (2001-11-01), None
J.L. Bos, Cancer Res., 1989, 49, 4682.
P.J. Casey, P.A. Solski, C.J. Der, J.E. Buss, Proc. Natl. Acad. Sci. U.S.A., 1989, 86, 8323.
J.F. Hancock, H. Paterson, C.J. Marshall, Cell, 1990, 63, 133.
Zask, et al., J. Med. Chem., 1990, 33, 1418-1423.
P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. McMohan, D. Vistica, J. Warren, J. Bokesh, S. Kenney, M.R. Boyd, J. Natl. Cancer Instit., 1990, 82(13), 1107-1112.
L.V. Rubinstein, R.H. Shoemaker, K.D. Paull, R.M. Simon, S. Tosini, P. Skehan, D.A. Scudiero, A. Monks, M.R. Boyd, J. Natl. Cancer Instit., 1990, 82(13), 1113-1118.
J.F. Moomaw, P.J. Casey, J. Biol. Chem., 1992, 267, 17438-17443.
M.A. Garcia, et al.,J. Biol. Chem., 1993, 268, 18415-18420.
G.L. Bolton, J.S. Sebolt-Leopold, J.C. Hodges; Annu. Rep. Med. Chem., 1994, 29, 165.
R.J.A. Grand in “New Molecular Targets in Cancer Chemotherapy”, J.D. Kerr and P. Workman, Eds. CRC Press, Boca Raton, FL., 1994, p. 97.
G.L. James, M.S. Brown, J.L. Goldstein, Methods in Enzymology, 1995, 255, 38-46.
M.R. Boyd, K.D. Paull, Drug Development Res., 1995, 34, 91-109.
S.P. Fricker, R.G. Buckley, Anticancer Research, 1996, 16, 3755-3760.
S. Ayral-Kaloustian, J.S. Skotnicki, Annu. Rep. Med. Chem., 1996, 31, 171.
T.M. Williams, Exp. Opin. Ther. Patents, 1998, 8, 553.
SCH-66336, Pharmaprojects, 1998, No. 5128.
R-115777, Pharmaprojects, 1998, No. 5532.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

3-substituted-3-(substitutedsulfonyl or sulfanyl)... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-substituted-3-(substitutedsulfonyl or sulfanyl)..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-substituted-3-(substitutedsulfonyl or sulfanyl)... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3402177

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.