Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-12-17
2009-02-17
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S250000
Reexamination Certificate
active
07491729
ABSTRACT:
3-Substituted 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof. The invention relates to 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives which are substituted in position 3 by 5-membered heteroaryl which may be fused to an aryl or heteroaryl radical, where the heteroaryl and, if appropriate, the fused aryl or heteroaryl radical may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2, —NH(R6), aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl, where the substituents aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2and —NH(R6). The preparation and use of these derivatives, especially for therapeutic purposes, e.g. for the treatment of depressions, are likewise described.
REFERENCES:
patent: 5932730 (1999-08-01), Riechers et al.
patent: 6159962 (2000-12-01), Steiner et al.
patent: 6159981 (2000-12-01), Steiner et al.
patent: 6222034 (2001-04-01), Steiner et al.
patent: 6355647 (2002-03-01), Steiner et al.
patent: 6387912 (2002-05-01), Steiner et al.
patent: 6750221 (2004-06-01), Garcia-Ladona et al.
patent: 7109205 (2006-09-01), Riechers et al.
patent: 7119097 (2006-10-01), Riechers et al.
patent: 2004/0048815 (2004-03-01), Herr
patent: 2004/0077638 (2004-04-01), Geneste
patent: 2004/0202656 (2004-10-01), Garcia-Ladona et al.
patent: 2006/0142317 (2006-06-01), Bakker et al.
patent: 2006/0159678 (2006-07-01), Geneste
patent: 2006/0235004 (2006-10-01), Geneste
patent: 2007/0098721 (2007-05-01), Hillen
patent: 2007/0203338 (2007-08-01), Riechers
patent: 2007/0299074 (2007-12-01), Netz
patent: 2008/0161322 (2008-07-01), Geneste
patent: 0 169 132 (1992-08-01), None
patent: WO 95/31988 (1995-11-01), None
patent: WO01/24827 (2001-04-01), None
patent: WO2008/064292 (2008-05-01), None
Cryan, J., et al., 5-HT1A and Beyond: The Role of Serotonin and its Receptors in Depression and the Antidepressant Response, Hum. Psychopharmacol. Clin. Exp. 15, 113-135 (2000).
S. J. Starkey et al. “5-HTiDas well as 5-HT1AAutoreceptors Modulate 5-HR Release in the Guinea-pig Dorsal Raphe Nucleus” Neuropharmacology 33,(¾) 1994 pp. 393-402.
Bakker Margaretha
Hornberger Wilfried
Kling Andreas
Lange Udo
Mack Helmut
Abbott & GmbH & Co. KG
Dykema Gossett PLLC
Leeser Erich A
Wilson James O.
LandOfFree
3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4082716