[3-substituted-2-(substituted imino)-4-oxo-5-thiazolidinylidene]

Details [3-substituted-2-(substituted imino)-4-oxo-5-thiazolidinylidene] [3-substituted-2-(substituted imino)-4-oxo-5-thiazolidinylidene]

1987-01-06

1988-10-04

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548184, C07D27754, A61K 31425

Patent

active

047756772

ABSTRACT:
The present invention provides novel [3-substituted-2-(substituted imino)-4-oxo-5-thiazolidinylidene]acetic acids, and novel pharmaceutical compositions and methods of use thereof. The novel acids of the invention are leukotriene antagonists having activity useful for treating asthma, allergies, cardiovascular diseases, migraines, and inflammation.

REFERENCES:
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Vogeli et al., Helvetica Chimica. Acta., vol. 61, Fasc. 2, No. 49, pp. 607-617, (1978).
Acheson et al., J. C. S., Perkin I, pp. 415-422, (1981).

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