Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-11-04
1999-07-06
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514359, 514361, 514362, 514363, 514364, 514369, 514374, 514376, 514383, 514386, 514414, 548100, 548131, 548133, 548135, 548136, 548185, 548190, 548229, 548230, 548255, 5482622, 5482632, 5482638, 5483114, 548486, A61K 3140, A61K 31425, C07D20934, C07D41706
Patent
active
059198095
ABSTRACT:
This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1## and the pharmaceutically-acceptable salts thereof which are inhibitors of prostaglandin H.sub.2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H.sub.2 synthase and interleukin-1 biosynthesis, per se, and as analgesic, antiinflammatory and antiarthritic agents in the treatment of chronic inflammatory diseases. This invention also relates to pharmaceutical compositions comprising said 3-substituted-2-oxindole derivatives; to methods of inhibiting prostaglandin H.sub.2 synthase and biosynthesis of interleukin-1; and to treating chronic inflammatory diseases in a mammal with said compounds. Further, this invention relates to certain novel carboxylic acids useful as intermediates in the preparation of the 3-substituted-2-oxindole derivatives of this invention and to a process for the preparation of the 3-substituted-2-oxindole derivatives.
REFERENCES:
patent: 3634453 (1972-01-01), McManus et al.
patent: 3900563 (1975-08-01), Allen, Jr. et al.
patent: 4556672 (1985-12-01), Kadin
patent: 4569942 (1986-02-01), Kadin
patent: 4690943 (1987-09-01), Kadin
patent: 4695571 (1987-09-01), Melvin
patent: 4721712 (1988-01-01), Kadin
patent: 4752609 (1988-06-01), Kadin
patent: 4808601 (1989-02-01), Kadin
patent: 4861794 (1989-08-01), Otterness
patent: 4962117 (1990-10-01), Young et al.
Carpenter, A. J. et al., Regioselective .beta.-and .delta.-Metallations of Thiophene Derivatives Bearing the 4,4-Dimethyloxazolin-2-yl Group. Application of the Method to Syntheses of 2,3-and 2,5-Disubstituted Thiophene
Derivatives, J. Chem. Soc. Perkin Trans I:173-181 (1985) (Carpenter I), 1985.
Thiophene and Furans, J. Org. Chem. 50:4362-4368 (1985) (Carpenter II), 1985.
2-Mercaptothiazol-4-ylthiophenecarboxylic acids, Chem. Abstr. 103:22580m (1985).
2-Azolyl-5-oxadiazolylthiophenes, Chem. Abstr. 63, column 4432 (1965).
A New Procedure for the Preparation of Ester-Containing Organosilanes, J. Org. Chem. 38:3660-3661 (1973).
Chem. Abstr. 49 columns 2233-2236 (1955).
Brooks, D. W. et al., C-Acylation under Virtually Neutral Conditions, Angew. Chem. Int. Ed. Engl. 18:72-74 (1979).
Staab, H. A.,, Aregewande Chem. 17:415 Part e (1962) (Angew. Chem. Internat. Edit. 1(7):351-367 (1962).
Baker, D. C., C-Acylation of Nitromethane. A Synthetic Route to .beta.-Nitroketones, Synthesis (1978) pp. 478-479.
Otterness, I. G. et al., Effects of CP-66,248 on IL-1 Synthesis by Murine Peritoneal Macrophages, Arthritis & Rheumatism 31 No. 4 (Supplement):S90 Abstract C55 (1988).
"Three Pfizer Drugs Promising; FDA Okay to be Sought in '89", Chemical Marketing Reporter, Sep. 14, 1987, p. 7.
FDC Reports "The Pink Sheet".RTM., Sep. 14, 1987, p. 2.
FDC Reports "The Pink Sheet".RTM., Sep. 28, 1987, p. 11.
Kobayashi, Goro et al., Chem. Abst. 69 (13):4854 (No. 5201v), Sep. 23, 1968.
Oki, Sadao et al., Chem. Abst. 78 (21):363 (No. 136057s), May 28, 1973.
Chem. Abst. 98 (21):659 (No. 179366x), May 23, 1983.
Ehrgott Frederick J.
Goddard Carl J.
Schulte Gary R.
Benson Gregg C.
Gupta Yogendra N.
Pfizer Inc.
Richardson Peter C.
LandOfFree
3-substituted-2-oxindole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3-substituted-2-oxindole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-substituted-2-oxindole derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-899348