Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-06-05
1994-03-01
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514365, 514369, 514370, 514371, 514372, 514374, 514376, 514377, 514378, 514380, 514385, 514386, 514397, 514403, 514404, 514406, 514407, 548112, 548181, 548182, 548183, 548184, 548185, 548186, 548187, A61K 31405, A61K 31415, A61K 3142, A61K 31425
Patent
active
052908020
ABSTRACT:
This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H.sub.2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H.sub.2 synthase and interleukin-1 biosynthesis, per se, and as analgesic, antiinflammatory and antiarthritic agents in the treatment of chronic inflammatory diseases This invention also relates to pharmaceutical compositions comprising said 3-substituted-2-oxindole derivatives; to methods of inhibiting prostaglandin H.sub.2 synthase and biosynthesis of interleukin-1; and to treating chronic inflammatory diseases in a mammal with said compounds. Further, this invention relates to certain novel carboxylic acids useful as intermediates in the preparation of the 3-substituted-2-oxindole derivatives of this invention and to a process for the preparation of the 3-substituted-2-oxindole derivatives.
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Ehrgott Frederick J.
Goddard Carl J.
Schulte Gary R.
Benson Gregg C.
Ford John M.
Gupta Y. N.
Pfizer Inc.
Richardson Peter C.
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