3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-in

Details 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-in 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-in

1984-12-21

1985-12-03

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514253, 514256, 514333, 514339, 514361, 514362, 514363, 514365, 514372, 514374, 514378, 514397, 514406, 514411, 514418, 544333, 544405, 546270, 546273, 548127, 548134, 548136, 548181, A61K 3140, C07D20934

Patent

active

045566720

ABSTRACT:
Certain new 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and anti-inflammatory agents in mammalian subjects. In particular, the compounds of the invention are useful for ameliorating or eliminating pain in human subjects recovering from surgery or trauma, and in alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis, in human subjects.

REFERENCES:
patent: 3190889 (1965-06-01), Shen
patent: 3462450 (1969-08-01), Shen
patent: 3519592 (1970-07-01), Holden
patent: 3631177 (1971-12-01), Holden
patent: 3634453 (1972-01-01), McManus et al.
patent: 3749731 (1973-07-01), Zinnes et al.
patent: 3856967 (1974-12-01), Allais et al.
patent: 3975531 (1976-08-01), Welstead et al.
patent: 4012394 (1977-03-01), Deschamps et al.
Pakula et al., Chemical Abstracts, 72:12563(k), (1970).
Brenner et al., Chemical Abstracts, 72:12565(n), (1970).
Shen et al., Chemical Abstracts, 72:12566(p), (1970).
Wenkert et al., Journal of the American Chemical Society, 80, 4899, (1958).
Bunnett et al., Organic Syntheses, vol. 40, 1, (1960).
El-Enany et al., Bulletin of the Faculty of Pharmacy, (Cairo University), 14, 29, (1975).
Buchel et al., Z. Anal. Chemie, 190, 243, (1962).

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