3-Substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic ac

Details 3-Substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic ac 3-Substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic ac

1980-08-08

1983-01-18

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

544144, 544373, 546200, 546272, 2602452T, 424263, C07D48704, C07D20508, A61K 3140

Patent

active

043691870

ABSTRACT:
Disclosed are 3-substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acids (I): ##STR1## wherein R is, inter alia, acyl, alkyl, and aralkyl. Such compounds and their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 4203902 (1980-05-01), Shih
patent: 4210661 (1980-07-01), Ponsford et al.
Fieser et al.; Advanced Organic Chemistry, p. 400 (1961).
Theilheimer; Synthetic Methods; vol. 19:240.

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