3-substituted-1-aryl-2(H)-quinolones and their pharmaceutical co

Details 3-substituted-1-aryl-2(H)-quinolones and their pharmaceutical co 3-substituted-1-aryl-2(H)-quinolones and their pharmaceutical co

1989-11-13

1991-11-12

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544182, 544238, 544333, 544405, 546157, A61K 3147, C07D215227

Patent

active

050648373

ABSTRACT:
Novel 3-substituted-1-aryl-2(1H)-quinolones useful as anti-allery, anti-inflammatory, anti-hyperproliferative skin disease agents are disclosed. The quinolones are represented by Formula 1: Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.

REFERENCES:
patent: 4277479 (1981-07-01), Nishi et al.
patent: 4735948 (1988-04-01), Wright
patent: 4748246 (1988-05-01), Skotnicki et al.
Chemical Abstract 211280h, vol. 91, No. 26 (24 Dec. 79) and Reg. No. 71978-18-2 (13 Jun. 79); and Derwent Abstract 55102b.
Chemical Abstract 221701e, vol. 108, No. 25 (20 Jun. 88), and Reg. No. 114560-96-2 and Reg. No. 114560-71-3 (21 Oct. 87).
Chemical Abstract 204453h, vol. 18, No. 14, (4 Apr. 88), and Reg. NO. 114125-87-0.
Chupp and Metz, Heterocycles from Substituted Amides, VI (1,2). J. heterocyclic Chem., 16. pp. 65-71, 1979.
Chemical Abstract 92023s, vol. 79, 1973.
Hayes, et al., J. Chem. Research(s) 414, (1980).
Meth-Cohn et al., J.C.S. Perkin I 1520 (1981).

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