3-Substituted-1,2-benzisoxazoles and pharmaceutically acceptable

Details 3-Substituted-1,2-benzisoxazoles and pharmaceutically acceptable 3-Substituted-1,2-benzisoxazoles and pharmaceutically acceptable

1973-03-12

1976-04-06

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602475EP, 260268BC, 2602564H, 424248, 424250, 424251, 424272, C07D26120

Patent

active

039489280

ABSTRACT:
3-Substituted-1,2-benzisoxazole derivative of the following formula: ##SPC1##
Wherein R.sub.1 is hydrogen, hydroxy, nitro, alkyl, alkoxy, halogen or amino; R.sub.2 is hydroxyamino, amino, hydrazino, mono- or di- alkyl substituted amino, aralkylamino, acyloxyamino, morpholino, piperazine which is unsubstituted or substituted with alkyl, aralkyl or aryl at 4 position, or pyrrolidino, or R.sub.2 may combine with imino group and form together with the adjacent carbon atom a heterocyclic ring such as imidazoline or tetrahydropyrimidine; and n is an integer of 0 to 3, and its pharmaceutically acceptable acid addition salt, and preparation thereof. The present compounds show valuable pharmacological properties, such as anti-reserpine activity, central nervous depressing activity, anti-hypertensive activity and l-dopa potentiating activity.

REFERENCES:
patent: 3673188 (1972-06-01), Harsanyi et al.
Smith, P.A.S. -- Chemistry of Open Chain Organic Nitrogen Compounds -- Vol. II -- W. A. Benjamin, Inc. (1966) -- p. 93.

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