3-spirocyclic indolyl derivatives useful as ORL-1 receptor...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S017000

Reexamination Certificate

active

07655670

ABSTRACT:
The present invention is directed to novel 3-spirocyclic indolyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the ORL-1 receptor.

REFERENCES:
patent: 2004/0152707 (2004-08-01), Tulshian et al.
patent: 2005/0038060 (2005-02-01), Ando et al.
patent: 2006/0079505 (2006-04-01), Makings et al.
Haynes et al. Stereoselective, Base-Induced Formation of Bicyclo[2.2.1] Heptanones and Bicyclo [3.2.1.] Octanols Formed from the Products of Conjugation Addition of Lithiated Allylic Sulfoxides and Phosphine Oxides to Cyclopean-2-enone. Australian Journal of Chemistry, Sep. 1989, vol. 42, No. 9, pp. 1473-1483, p. 1473, abstract.

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