3-[(S)-1'-phenylethylamino]propylaminobleomycin, non-toxic salt

Details 3-[(S)-1'-phenylethylamino]propylaminobleomycin, non-toxic salt 3-[(S)-1'-phenylethylamino]propylaminobleomycin, non-toxic salt

1979-07-18

1980-12-09

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

536 17R, 424177, C07C10352

Patent

active

042383919

ABSTRACT:
Novel 3-[(S)-1'-phenylethylamino]propylaminobleomycin obtained by reacting a reactive derivative of the carboxyl group of bleomycinic acid with N-[(S)-1'-phenylethyl]-1,3-diaminopropane, a non-toxic salt of said novel bleomycin, and a method for producing the novel bleomycin. Because of much reduction in the side effect causing pulmonary fibrosis, the novel bleomycin is more useful than a commercial bleomycin complex which gives rise to said undesirable side effect.

REFERENCES:
patent: 3922262 (1975-11-01), Umezawa et al.
patent: 3971822 (1976-07-01), Chibata et al.
patent: 4007219 (1977-02-01), Hassall et al.
patent: 4032567 (1977-06-01), Klieger et al.
patent: 4128542 (1978-12-01), Atherton et al.

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