3-[(S)-1'-Phenylethylamino]propylaminobleomycin, non-toxic salt

Details 3-[(S)-1'-Phenylethylamino]propylaminobleomycin, non-toxic salt 3-[(S)-1'-Phenylethylamino]propylaminobleomycin, non-toxic salt

1978-06-15

1980-03-25

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

536 17R, 424177, C07C10352, A61K 37100

Patent

active

041950186

ABSTRACT:
Novel 3-[(S)-1'-phenylethylamino]propylaminobleomycin obtained by reacting a reactive derivative of the carboxyl group of bleomycinic acid with N-[(S)-1'-phenylethyl]-1,3-diaminopropane, a non-toxic salt of said novel bleomycin, and a method for producing the novel bleomycin. Because of much reduction in the side effect causing pulmonary fibrosis, the novel bleomycin is more useful than a commercial bleomycin complex which gives rise to said undesirable side effect.

REFERENCES:
patent: 3846400 (1974-11-01), Umezawa et al.
patent: 3984390 (1976-10-01), Umezawa et al.

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