3-Quinolinecarbonitrile protein kinase inhibitors

Details 3-Quinolinecarbonitrile protein kinase inhibitors 3-Quinolinecarbonitrile protein kinase inhibitors

2005-02-16

2008-11-11

Solola, Taofiq A (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S252110, C514S318000, C544S109000, C544S357000, C546S194000

Reexamination Certificate

active

07449460

ABSTRACT:
This invention provides a compound of Formula 1where Ar, X, R1, R2, R3, and R4are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.

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