3-Quaternary ammonium methyl)-substituted cephalosporin derivati

Details 3-Quaternary ammonium methyl)-substituted cephalosporin derivati 3-Quaternary ammonium methyl)-substituted cephalosporin derivati

1982-03-29

1984-07-03

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 22, 544 25, A61K 31545, C07D50146

Patent

active

044579292

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, R.sup.2 and R.sup.3 each are independently methyl or ethyl, and R.sup.4 is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, allyl, 2-butenyl, 3-butenyl, 2-hydoxyethyl, 3-hydroxypropyl, 2-(dimethylamino)ethyl, pyridylmethyl, pyridylethyl, benzyl or phenethyl, and nontoxic pharmaceutically acceptable acid addition salts and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.

REFERENCES:
patent: 4278671 (1981-07-01), Ochiai et al.
patent: 4278793 (1981-07-01), Durckheimer et al.

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