3-Pyrrolo[ b ]cyclohexylene-2-dihydroindolinone derivatives...

Details 3-Pyrrolo[ b ]cyclohexylene-2-dihydroindolinone derivatives... 3-Pyrrolo[ b ]cyclohexylene-2-dihydroindolinone derivatives...

2007-12-03

2011-12-27

Saeed, Kamal (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S414000

Reexamination Certificate

active

08084621

ABSTRACT:
3-pyrrolo[b]cyclohexylene-2-dihydro-indolinone derivatives of formula (I) or their pharmaceutically acceptable salts and uses thereof. The intermediates of formula (II) for preparing the above compounds. The bioassay shows that the above compounds and their pharmaceutically acceptable salts can modulate the activity of protein kinases (PKs), inhibit the activity of tyrosine kinases (PTKs) and inhibit many kinds of tumor cells as well as.

REFERENCES:
patent: 6642251 (2003-11-01), Tang et al.
patent: WO 00/12084 (2000-03-01), None
patent: WO 01/37819 (2001-05-01), None
patent: WO 01/60814 (2001-08-01), None
patent: WO 02/092079 (2002-11-01), None
patent: WO 03/035009 (2003-05-01), None
patent: WO 2005/053686 (2005-06-01), None

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