[3-(Pyridinium)-7-(naphthyiridinyl carbonylamino)acetamido]cepha

Details [3-(Pyridinium)-7-(naphthyiridinyl carbonylamino)acetamido]cepha [3-(Pyridinium)-7-(naphthyiridinyl carbonylamino)acetamido]cepha

1978-11-02

1980-04-15

Wheeler, David

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D50146

Patent

active

041985044

ABSTRACT:
7-[.alpha.-(4-hydroxy-1,5-naphthyridine-3-carboxamido)-.alpha.-phenyl or thienyl (and substituted phenyl) acetamido]-3-(pyridiniummethyl)-3-cephem-4-carboxylates having on the pyridine ring an acidic group which is preferably --COOH or --SO.sub.3 H and also, if desired, having one or two methylene groups together with or without a hetero atom between the pyridine ring and the acidic group were synthesized and found to have potent antibacterial activity in vitro especially against many strains of Pseudomonas aeruginosa and also high solubility in water.

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