3-Propenzl cephalosporin isomer separation process and derivativ

Details 3-Propenzl cephalosporin isomer separation process and derivativ 3-Propenzl cephalosporin isomer separation process and derivativ

1985-11-25

1988-02-23

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540215, 540220, 540222, A61K 31545, C07D50112

Patent

active

047270705

ABSTRACT:
The antibiotic 7-[D-2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-1-propenyl]ceph-3-em-4-c arboxylic acid (BMY-28100) forms imidazolidinone derivatives on reaction with ketones. These derivatives are useful in pharmaceutical dosage forms and as intermediates for separation thereof from mixtures containing the [(E)-1-propenyl]isomer of the antibiotic.

REFERENCES:
patent: 4339575 (1982-07-01), Ko'Oka et al.
patent: 4473567 (1984-09-01), Ko'Oka et al.
patent: 4520022 (1985-05-01), Hoshi et al.

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