3-(Piperidino-lower-alkyl)-indoles

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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26032615, 424267, 424274, C07D40106

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active

040214311

ABSTRACT:
1-Acyl-3-(amino-lower-alkyl)indoles, useful as anti-inflammatory agents, are prepared either by acylation of a 3-(amino-lower-alkyl)indole; by Fisher indole synthesis from an N'-acylphenylhydrazine and an amino-lower-alkanone; by alkylation of an amine with a 1-acyl-3-(halo-lower-alkyl)indole; or by reductive alkylation of a 1-acyl-3-indole-lower-alkylcarboxaldehyde.

REFERENCES:
patent: 3238215 (1966-03-01), Zenitz
patent: 3285908 (1966-11-01), Shen
patent: 3527761 (1970-09-01), Archibald et al.
patent: 3564009 (1971-02-01), Yamamoto et al.
patent: 3686213 (1972-08-01), Poletto et al.

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