3-Piperazinyl 1,2,4-benzothiadiazine 1,1-dioxide derivatives the

Details 3-Piperazinyl 1,2,4-benzothiadiazine 1,1-dioxide derivatives the 3-Piperazinyl 1,2,4-benzothiadiazine 1,1-dioxide derivatives the

1975-10-28

1977-06-14

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260243D, C07D28524, A61K 3154

Patent

active

040297802

ABSTRACT:
A compound of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a lower alkyl group, and R.sub.2 represents a hydrogen or halogen atom or a trifluoromethyl group,
And its pharmaceutically acceptable salt. The compound is prepared by reacting the corresponding 1,2,4-benzothiadiazine 1,1-dioxide with a piperazine compound or alkylating 1,2,4-benzothiadiazine 1,1-dioxide whose corresponding 3-position is substituted by a piperazinyl group. The above compound has superior antihypertensive activity separated from diuretic, antidiuretic and hyperglycemic activities, and is free from side-effects.

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patent: 3960854 (1976-06-01), Novello
Cronin et al., "J. of Med. Chemistry" vol. 11, 1968, pp. 136-138, RS-1-J5.
Sprague, "Annals: New York Academy of Sciences", 1958, vol. 71, pp. 328-343.
Yale et al., "JACS", vol. 82, 1960, pp. 2042-2043
Norrison et al., "Organic Chemistry", 1966, p. 74.

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