Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-12-25
2007-12-25
Stockton, Laura L. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S222000, C514S375000
Reexamination Certificate
active
11298920
ABSTRACT:
The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C1-C4-alkyl group; Y represents NH, N—C1-C10-alkyl, O, or S; Z represents NH, N—C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C1-C10-alkyl, N-aryl, NSO2—C1-C10-alkyl, N—SO2-aryl, or N—SO2-heteroaryl; R1to R8each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments
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Lazer et al., Journal of Medicinal Chemistry, 1994, 37(7), pp. 913-923.
J. L. Collins et al., “N-(2-Benzoylphenyl)- L- Tyrosine PPARgamma Agonists. 2. Structure-Activity Relationship and Optimization of the Phenyl Alkyl Ether Moiety.”, J. Med. Chem. vol. 41, pp. 5037-5054, (1998). XP-002211273.
J. E. Cobb et al., “N-(2-Benzoylphenyl)-L-tyrosine PPARgamma Agonists. 3. Structure-Activity Relationship and Optimization of the N-Aryl Substituent”, J. Med. Chem. vol. 41, pp. 5055-5069 (1998). XP-002156427.
Kowalczyk Piotr
Kurowski Krzysztof
Majka Zbigniew
Matusiewicz Katarzyna Joanna
Rusin Katarzyna Ewa
ADAMED Sp. z.o.o.
Darby & Darby PC
Stockton Laura L.
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