Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-02-12
1991-02-12
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540488, A61K 3155, C07D28106
Patent
active
049924320
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is phenyl substituted with 1 to 3 substituents selected from the group consisting of halogen and lower alkoxy; R.sub.2 is hydrogen, lower alkyl, lower alkanoyl, lower cycloalkanoyl, ##STR2## R.sub.3 and R.sub.4 are independently lower alkyl, phenyl lower alkyl or together form a piperidine or pyrrolidine ring; n is 2 ro 4; m is 1 to 2; and pharmaceutically acceptable acid addition salts thereof, with the proviso that when R.sub.1 is 4-methoxyphenyl, R.sub.2 is hydrogen and R.sub.3 and R.sub.4 are methyl; and n is 2, the compound of formula I cannot be in the (-)-cis form,
are described. The compounds of formula I are active as calcium channel blockers and accordingly, are useful as agents for treating ischemia.
REFERENCES:
patent: 4808580 (1989-02-01), Mohacsi et al.
Mohacsi Erno
O'Brien Jay P.
Bond Robert T.
Ciambrone Coletti Ellen
Gould George M.
Hoffmann-La Roche Inc.
Leon Bernard S.
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