3-Phenyl-1,2,4-oxadiazole derivatives as antiinflammatory-antitu

Details 3-Phenyl-1,2,4-oxadiazole derivatives as antiinflammatory-antitu 3-Phenyl-1,2,4-oxadiazole derivatives as antiinflammatory-antitu

1976-04-08

1978-01-10

Rush, Raymond V.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

260307G, A61K 3142, C07D27106

Patent

active

040679888

ABSTRACT:
3-Phenyl-1,2,4-oxadiazole derivatives of the formula ##STR1## wherein R is selected from the group consisting of --(CH.sub.2).sub.m --COR.sub.1, ##STR2## m is 2, 3 or 4, R.sub.1 is selected from the group consisting of hydroxy, alkoxy of 1 to 4 carbon atoms and ##STR3## n is 1 or 2, X is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R.sub.2 is selected from the group consisting of hydroxy, alkoxy of 1 to 4 carbon atoms, ##STR4## and --NH--(CH.sub.2).sub.n --COR.sub.1 and p is 1, 2, 3 or 4 and the non-toxic, pharmaceutically acceptable salts thereof which have respiratory anti-inflammatory and peripheric antitussive properties and their preparation.

REFERENCES:
patent: 3270028 (1966-08-01), Palazzo
patent: 3879407 (1975-04-01), Hagarty
patent: 3887573 (1975-06-01), Breuer et al.

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