3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and relate

Details 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and relate 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and relate

1977-03-30

1978-09-19

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D51904

Patent

active

041153880

ABSTRACT:
3'-hydroxy and 3'-keto derivatives of 4'-deoxy VLB (deoxy VLB "A"), 4'-deoxyleurosidine (deoxy VLB "B"), 4'-deoxyvincristine and 4'-deoxy-1-desmethyl-1-formylleurosidine and related 4-desacetyl and C-3 carboxamide derivatives, useful as anti-tumor agents in mammals.

REFERENCES:
patent: 3352868 (1964-04-01), Neuss et al.
patent: 3887565 (1975-06-01), Jones et al.
patent: 3944554 (1976-03-01), Tafur
Neuss et al., "Tetrahedron Letters," 811, (1967).
Ibid., 783 (1968).

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