3-Oxoalkylidene-2-azetidinone derivatives

Details 3-Oxoalkylidene-2-azetidinone derivatives 3-Oxoalkylidene-2-azetidinone derivatives

1987-10-05

1989-02-07

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20508, C07D20510, C07D40504, A61K 31395

Patent

active

048032662

ABSTRACT:
2-Azetidione derivatives represented by the following formula ##STR1## wherein X is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group or a cyano group, l is 1 or 2, R.sup.1 is a lower alkyl group, a cycloalkyl group, a 1-naphthylmethyl group, an optionally substituted phenethyl group, an optionally substituted phenyl group, an optionally substituted benzyl group or a bis(alkoxycarbonyl)ethyl group, and R.sup.2 is a lower alkyl group, a lower alkoxy group, an amino group, an adamantyl group, a lower alkoxycarbonylmethyl group or an optionally substituted phenyl group, are disclosed. These compounds are useful as blood platelet aggregation inhibiting agents.

REFERENCES:
Buynak, Chem. Abs. 103, 178073 (1985).
Tetrahedron, vol. 41 (1985) Mori et al., pp. 375-385, "New Synthesis of .beta.-Lactames".
Liebigs Annalen der Chemie, Heft 5, 1983, pp. 1153, 1158, 1165-1168, "Darstellung und Stereochemie von 3-(.alpha.-Hydroxybenzyl(-1, 4-diphen".
Archiv der Pharmazie, vol. 319, 1986, Bergmann et al., pp. 203-216, "Zur N- unc C-Silylierung von .beta.-Lactamen".
Tetrahedron Letters, vol. 25, 1984, Manhas et al., p. 4735, "A Convenient Synthesis of Azetidine-2-3-Diones".

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