3-Oxo-5,6-dihydro-1,2,4-oxadiazines useful as antiandrogenic age

Details 3-Oxo-5,6-dihydro-1,2,4-oxadiazines useful as antiandrogenic age 3-Oxo-5,6-dihydro-1,2,4-oxadiazines useful as antiandrogenic age

1976-10-05

1978-08-22

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424852, A01N 900, A01N 922

Patent

active

041089936

ABSTRACT:
Antiandrogenic compositions comprising an effective amount of at least one compound of the formula ##STR1## wherein X and Y are individually selected from the group consisting of hydrogen, halogen, --CF.sub.3, --NO.sub.3 and alkylthio of 1 to 4 carbon atoms and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, benzyl and hydroxymethyl and an inert pharmaceutical carrier and a method of inducing antiandrogenic activity in warm-blooded animals as well as novel oxadiazines of formula I with the proviso that when R is other than benzyl or hydroxymethyl at least one of X and Y is alkylthio of 1 to 4 carbon atoms.

REFERENCES:
patent: 3238200 (1966-03-01), Bernstein et al.
patent: 3537839 (1970-11-01), Steinbrunn et al.
patent: 3625968 (1971-12-01), Zschocke et al.
patent: 3696099 (1972-10-01), Makula et al.
patent: 3829419 (1974-08-01), Weir

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