3-Oxo-4-halo-16.beta.-methylandrost-4-ene 17.beta.-carboxylic ac

Details 3-Oxo-4-halo-16.beta.-methylandrost-4-ene 17.beta.-carboxylic ac 3-Oxo-4-halo-16.beta.-methylandrost-4-ene 17.beta.-carboxylic ac

1979-08-29

1981-07-14

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603971, 26023955R, 26039745, A61K 3156

Patent

active

042786690

ABSTRACT:
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17.beta.-carboxylic acids (and esters thereof) substituted at the 4-position with a fluoro or chloro, optionally substituted at the 6- position with fluoro or chloro and at 16.beta. with methyl are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9.alpha. position with fluoro, chloro or bromo; substituted at the 11 with a keto, a beta-hydroxy or a beta-chloro (the latter only when there is a 9.alpha.-chloro); when there is a 17.alpha.-hydroxy (or an ester).

REFERENCES:
patent: 3479341 (1969-11-01), Ledig et al.
patent: 4093721 (1978-06-01), Phillipps et al.

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