3-oxiranyl benzoic acids and derivatives thereof

Details 3-oxiranyl benzoic acids and derivatives thereof 3-oxiranyl benzoic acids and derivatives thereof

1992-11-16

1999-11-23

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514475, C07D30316

Patent

active

059903260

ABSTRACT:
The present invention relates to compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R is alkyl of 12 carbon atoms, alkenyl of 12 carbon atoms having from 1 to 4 --CH.dbd.CH-- groups when the carbon adjacent to R is saturated and from 1 to 2 --CH.dbd.CH-- groups when the carbon adjacent to R is unsaturated, aryl, heterocyclo, alkoxyalkyl wherein the alkyl groups have 1 to 6 carbon atoms, or aryloxyalkyl wherein the alkyl group has 1 to 6 carbon atoms R.sup.1 is hydrogen, lower alkyl, or a pharmaceutically acceptable cation. These compounds are inhibitors of leukotriene A.sub.4 (LTA.sub.4) hydrolase.

REFERENCES:
patent: 4665189 (1987-05-01), Baker et al.
patent: 4675335 (1987-06-01), Baker et al.
J. Evans, et. al., Prostaglandins, Leukotrienes and Medicine 23: 167-171 (1986).
R. A. Lewis, et. al., J. Clin. Invest., 73: 889-897 (1984).

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