3-Oxaprostaglandins

Details 3-Oxaprostaglandins 3-Oxaprostaglandins

1983-12-06

1985-07-16

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562503, 568379, 556443, C07C17700

Patent

active

045298122

ABSTRACT:
This invention relates to novel 3-oxa-15-desoxy-16-hydroxy-16-alkyl prostaglandins of the E.sub.2 series and the 5,6-acetylene derivatives thereof. These compounds are useful for their gastric antisecretory, cytoprotective, antiulcer, and antihypertensive activity. In addition the invention also discloses certain novel trialkylsilyl acetylenic intermediates.

REFERENCES:
patent: 4170597 (1979-10-01), Wissner
patent: 4254285 (1981-03-01), Wissner
patent: 4429148 (1984-01-01), Floud

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