3-Oxadiazol-5-yl-1-aminoalkyl-1h-indole derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C548S131000, C546S196000, C544S062000, C544S367000

Reexamination Certificate

active

06930118

ABSTRACT:
The invention provides aminoalkylindole compounds of Formula (I), wherein R1-R5, n and p are as described. Also provided are compositions containing compounds of Formula (I) and the use of compounds of Formula (I) in modulating the activity of a cannabinoid receptor in a subject. In particular, the invention provides the use of such compounds as analgesic agents

REFERENCES:
patent: 4939138 (1990-07-01), D'Ambra et al.
patent: 4973587 (1990-11-01), Ward et al.
patent: 5013837 (1991-05-01), Ward et al.
patent: 5068234 (1991-11-01), D'Ambra et al.
patent: 5998409 (1999-12-01), Gaster et al.
patent: 6013648 (2000-01-01), Rinaldi et al.
patent: 0 328 200 (1989-08-01), None
patent: WO 93/02677 (1993-02-01), None
patent: WO 96/25397 (1996-08-01), None
Kelarev et al., Zhumal Organicheskoi Khimii (1993), 29(4), pp. 763-769.
Kelarev et al., Khimicheskaya Tecknologiya (1993), 36(3), pp. 49-55.
Chemical Abstracts 120:270260, 1994.
Chemical Abstracts 120:77192, 1994.
D'Ambra, T. et al., “Conformationally Restrained Analogues of Pravodoline: Nanomolar Potent, Enantioselective, (Aminoalkyl) Indole Agonists of the Cannabinoid Receptor,”J. Med. Chem.35:124-135, 1992.
D'Ambra, T. et al., “C-Attached Aminoalkylindoles:Potent Cannabinoid Mimetics,”Bioorganic&Medicinal Chemistry Letters6(1):17-22,1996.
Di Marzo, V. et al., “The Endogenous Cannabinoid Signalling System: Chemistry, Biochemistry and Physiology,”Internet Journal of Science—Biological Chemistry, Feb. 1997.
Dutta, A. et al., “Synthesis, Pharmacology, and Molecular Modeling of Novel 4-Alkyloxy Indole Derivatives Related to Cannabimimetic Aminoalkyl Indoles (AAIs),”Bioorganic and Medicinal Chemistry5(8):1591-1600, 1997.
Eissenstat, M. et al., “Aminoalkylindoles: Structure—Activity Relationship of Novel Cannabinoid Mimetics,”J. Med. Chem.38:3094-3105, 1995.
Hanus, L. et al., “HU-308: A Specific Agonist for CB2, a Peripheral Cannabinoid Receptor,”Proc. Natl. Acad. Sci. USA96(25):14228-14233, Dec. 1999.
Swain, C. et al., “Novel 5-HT3 Antagonists. Indole Oxadiazoles,”J. Med. Chem.34:140-151, 1991.
Williams, M. et al., “Emerging Molecular Approaches to Pain Therapy,”J. Med. Chem.42(9):1481-1500, May 1999.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

3-Oxadiazol-5-yl-1-aminoalkyl-1h-indole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-Oxadiazol-5-yl-1-aminoalkyl-1h-indole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-Oxadiazol-5-yl-1-aminoalkyl-1h-indole derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3452595

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.