Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-05-08
2007-05-08
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S374000, C514S210200, C514S227800, C514S235800, C514S254020, C514S326000, C544S060000, C544S138000, C544S369000, C546S209000, C548S131000
Reexamination Certificate
active
10731707
ABSTRACT:
Compounds of formula (I):wherein the substituents are as defined herein, and their salt, solvates, and prodrugs are procollagen C-proteinase (PCP) inhibitors useful in treating conditions mediated by PCP.
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patent: 0147901 (2001-05-01), None
Floyd C., et al, “Rapid Synthesis of Matrix Metalloproteinase Inhibitors via Ugi Four-Component Condensation”, SYNLETT, Jun. 1998, p. 637.
Dankwardt et al., “Solid-Phase Synthesis of Di- and Tripeptidic Hydroxamic Acids as Inhibitors of Procollagen C-proteinase”,Bioorganic&Medicinal Chemistry Letters, vol. 10, pp. 2513-2516, 2000.
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Fray et al., “Selectivity of Inhibition of Matrix Metalloproteases MMP-3 and MMP-2 by Succinyl Hydroxamates and their Carboxylic Acid Analogues is Dependent on P3′ Group Chirality”,Bioorganic&Medicinal Chemistry Letters, vol. 11, pp. 567-570, 2001.
Yamamoto et al., “Inhibition of Membrane-Type 1 Matrix Metalloproteinase by Hydroxamate Inhibitors: An Examination of the Subsite Pocket”,J. Med. Chem., vol. 41, No. 8, pp. 1209-1217, 1998.
Datta Usa
Fish Paul Vincent
James Kim
Whitlock Gavin Alistair
Ashbrook Charles W.
Dixon J. Michael
Pfizer Inc
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