Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-02-21
1990-06-19
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548543, 548544, A61K 3110, C07D20736, C07D20732
Patent
active
049354400
ABSTRACT:
3-[.omega.-(3,5-Di-t-butyl-4-hydroxyphenyl)alkanoyl]-pyrroles and their de-oxy analogs, for example, 3-(3,5-di-t-butyl-4-hydroxybenzyl)pyrrole, 2-chloro-4-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole, 3-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole and 3-[2-(3,5-di-t-butyl-4-hydroxyphenyl)-1-oxoethyl]pyrrole, have high pharmacological potency as anti-inflammatory, analgesic and antipyretic agents.
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Moore et al., "2,6-Di-tert-butyl-4-(2'-theonyl)phenol (R-830): A Novel Nonsteroidal Anti-Inflammatory Agent with Antioxidant Properties", Agents and Actions, 12(5): 674-683 (1982).
Hidaka et al., "Inhibition of Cyclooxygenase and 5-lipoxygenase by a New Antiinflammatory Drug, .alpha.-(3,5-Di-t-butyl-4-hydroxybenzylidene)-.gamma.-butyrolactone", Chem. Abs., 103: 15391p, Ensho, 3(4): 511-512 (1983).
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Greenhouse Robert
Muchowski Joseph M.
Murthy D. V. Krishna
Young John
Lowin David A.
Moran Tom M.
Springer David B.
Syntex (U.S.A.) Inc.
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