3-(.omega.-(3,5,-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles,

Details 3-(.omega.-(3,5,-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles, 3-(.omega.-(3,5,-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles,

1986-11-25

1989-05-23

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548530, 548539, C07D207333, A61K 3140, A61K207325, A61K20730

Patent

active

048331554

ABSTRACT:
3-[.omega.-(3,5-Di-t-butyl-4-hydroxyphenyl)alkanoyl]-pyrroles and their de-oxy analogs, for example, 3-(3,5-di-t-butyl-4-hydroxybenzyl)pyrrole, 2-chloro-4-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole, 3-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole and 3-[2-(3,5-di-t-butyl-4-hydroxyphenyl)-1-oxoethyl]pyrrole, have high pharmacological potency as anti-inflammatory, analgesic and antipyretic agents.

REFERENCES:
patent: 4000160 (1976-12-01), Bailey
patent: 4124725 (1978-11-01), Moore
patent: 4418074 (1983-11-01), Moore
Isomura et al., Chem. Pharm. Bull., 32, pp. 152-165 (1984).

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