3-O-Oleandrosyl-5-O-desosaminyl erythronolide compounds

Details 3-O-Oleandrosyl-5-O-desosaminyl erythronolide compounds 3-O-Oleandrosyl-5-O-desosaminyl erythronolide compounds

1982-01-08

1984-01-31

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424181, 424180, 435 74, 435172, 435253, A61K 3171, C07H 1708, C12P 1962

Patent

active

044291159

ABSTRACT:
The fermentation of a substrate selected among erythronolide B, erythronolide A and erythronolide A oxime with a novel mutant, Streptomyces antibioticus ATCC 31771, obtained from an industrial stock for the production of oleandomycin, said novel mutant being incapable of producing the same oleandomycin, permits novel macrolide antibiotics to be produced, having not only an activity range like that of erythromycin, but characterized by a greater stability in acidic environment, whereby for the administration of antibiotic it is no longer necessary to have recourse to esters and/or salts highly toxic for the organism.

REFERENCES:
patent: 4036853 (1977-07-01), Sciavolino
patent: 4069379 (1978-01-01), Sciavolino
patent: 4085119 (1978-04-01), Myers

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