3-O-Demethyl derivatives of the istamycin B series of compounds

Details 3-O-Demethyl derivatives of the istamycin B series of compounds 3-O-Demethyl derivatives of the istamycin B series of compounds

1981-09-03

1985-02-12

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 168, 536 179, 536 161, A61K 3171, C07H 1522

Patent

active

044990839

ABSTRACT:
New derivatives of the istamycin B series of compounds are provided, which are 3-O-demethylistamycin B.sub.O, 3-O-demethylistamycin B and 3-O-demethyl-2"-N-formimidoylistamycin B represented generally by Formula I or specifically by Formulae Ia, Ib and Ic, respectively. Compound Ia is useful as an intermediate for the preparation of Compounds Ib and Ic and the latter two compounds exhibit a high antibacterial activity against a wide variety of Gram-positive and Gram-negative bacteria and are useful antibiotics. Also provided are processes for the preparation of the new derivatives starting from istamycin B.sub.O.

REFERENCES:
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Egan et al., "Jour. Antibiotics", vol. 30, No. 7, 1977, pp. 552-562.
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Ikeda, "Jour. Antibiotics", vol. 33, No. 11, pp. 1281-1288.
Horiuchi et al., "Jour. Antibiotics", vol. 33, No. 12, pp. 1577-1580.

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