3-O-benzyl-2,4,6-tridooxy-6-iodo-alpha-D-erythro-hexopyranide us

Details 3-O-benzyl-2,4,6-tridooxy-6-iodo-alpha-D-erythro-hexopyranide us 3-O-benzyl-2,4,6-tridooxy-6-iodo-alpha-D-erythro-hexopyranide us

1986-04-28

1987-07-28

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

536 184, C07D30906

Patent

active

046833145

ABSTRACT:
Totally synthetic analogs of the known inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, compactin and mevinolin, are prepared from a chiral synthon derived from D-glucose which has the same chirality as the natural products.

REFERENCES:
Fieser et al., Reagents for Organic Synthesis, vol. 1, 1088-1089, (1967).
Fieser et al., ibid., vol. 4, 456, (1974).

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