3-O-acylated derivatives of (+)-cyanidan-3-ol

Details 3-O-acylated derivatives of (+)-cyanidan-3-ol 3-O-acylated derivatives of (+)-cyanidan-3-ol

1984-07-02

1986-10-14

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514337, 514456, 546269, 549220, 549399, A61K 3135, C07D31162

Patent

active

046172963

ABSTRACT:
The subject of the present invention is new O-substituted derivatives of (+)-cyanidan-3-ol corresponding to the general formula I ##STR1## in which R represents an optionally substituted hydrocarbon radical; an acyl radical of an organic carboxylic acid containing at least 2 carbon atoms, of a carbonic acid or of an organic sulphonic acid; or a radical of an inorganic acid containing at least one oxygen atom, with the exception of a glucosidic radical,
and the salts thereof, a process for the preparation thereof as well as their application in therapeutics and medicaments containing these new products.
These compounds have a valuable activity in the prevention of hepatic necrosis and also inhibit lipoperoxidation. In addition, they are capable of acting on the fibrillation of collagen.

REFERENCES:
patent: 4166861 (1979-09-01), Bonati et al.
Cetta et al., Ital. J. Biochem., 26, 317 (1977).
Weinges et al., Liebigs Ann. Chem., 714, 193 (1968).
Freundberg et al., Ber., 55, 1734 (1922).

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