3-O-acyl-4"-deoxydesmycosin derivatives

Details 3-O-acyl-4"-deoxydesmycosin derivatives 3-O-acyl-4"-deoxydesmycosin derivatives

1985-09-30

1987-03-24

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1708

Patent

active

046526382

ABSTRACT:
Novel 3-O-acyl-4"-deoxydesmycosin derivatives of the formula ##STR1## wherein R.sub.1 is lower alkyl, phenyl, substituted phenyl, phenyl-lower alkyl or substituted phenyl-lower alkyl, R.sub.2 is hydrogen or --CHO and R.sub.3 is hydrogen or hydroxyl, or a non-toxic salt thereof, can be produced by acylating the hydroxyl group at position-3 of the corresponding intermediate while protecting the hydroxyl at position-2' or positions-2' and -4' with acetyl, and then removing the protective group or groups. These derivatives have antibiotic utility against Gram positive and Gram negative bacteria.

REFERENCES:
patent: 4415730 (1983-11-01), Fujiwara et al.
patent: 4421911 (1983-12-01), Fujiwara et al.
patent: 4459290 (1984-07-01), Kirst et al.
Migrdichian, Organic Chemistry, vol. 1, 1957, p. 311.

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