Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-09-16
1995-08-01
Robinson, Douglas W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 187, 536 221, 536 261, 536 269, 536 287, 536 288, 536 289, C07H 1512, C07H 1700, C07H 504, C07H 1900
Patent
active
054381312
ABSTRACT:
Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each R.sub.n is H, OH, F or OCH.sub.3 ;
REFERENCES:
patent: Re29835 (1978-11-01), Witkowski et al.
patent: 3798209 (1974-03-01), Witkowski et al.
patent: 3984396 (1976-10-01), Witkowski et al.
patent: 4531001 (1985-07-01), Robins et al.
D. Bergstrom, "In Search of the Universal Nucleic Acid Base," Department of Health and Human Services Public Health Service Grant Application (1990).
D. Bergstrom, "An Efficient Route to C-4 Linked Imidazole Nucleosides: Synthesis of 2-Carbamoyl-4-(2'-Deoxy-.beta.-D-Ribofuranosyl)Imidazole," 32 Tetrahedron Letters 6485-6488 (1991).
U. B. Gyllensten, "PCR and DNA Sequencing," 7 BioTechniques 700-708 (1989).
F. Sanger, S. Nicklen and A. R. Coulson, "DNA Sequencing With Chain-Terminating Inhibitors," 74 Proc. Natl. Acad. Sci. USA 5463-5467 (1977).
F. Sanger, "Determination of Nucleotide Sequences in DNA," 214 Science 1205-1210 (1981).
A. Williamson and E. Rybicki, "Antisense Nucleic Acid Technology and Gene Regulation," 87 South African Journal of Science 478-480 (1991).
S. T. Crooke, "Therapeutic Applications of Oligonucleotides," 10 Bio/Technology 882-886 (1992).
P. D. Cook, "Medicinal Chemistry of Antisense Oligonucleotides-Future Opportunities," 6 Anti-Cancer Drug Design 585-607 (1991).
L. Leserman, G. Degols, P. Machy, J. Leonetti, N. Mechti and B. Leblue, "Targeting and Intracellular Delivery of Antisense Oligonucleotides Interfering With Oncogene Expression," Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS 25-33 (1991).
Y. Takahashi, K. Kato, Y. Hayashizaki, T. Wakabayashi, E. Ohtsuka, S. Matsuki, M. Ikehara and K. Matsubara, "Molecular Cloning of the Human Cholecystokinin Gene by Use of a Synthetic Probe Containing Deoxyinosine," 82 Proc. Natl. Acad. Sci. USA 1931-1935 (1985).
E. Ohtsuka, S. Matsuki, M. Ikehara, Y. Takahashi and K. Matsubara, "An Alternative Approach to Deoxyoligonucleotides as Hybridization Probes by Insertion of Deoxyinosine at Ambiguous Codon Positions," 260 The Journal of Biological Chemistry 2605-2608 (1985).
W. M. McShan, R. D. Rossen, A. H. Laughter, J. Trial, D. J. Kessler, J. G. Zendegui, M. E. Hogan and F. M. Orson, "Inhibition of Transcription of HIV-1 in Infected Human Cells by Oligodeoxynucleotides Designed to Form DNA Triple Helices," 267 The Journal of Biological Chemistry 5712-5721 (1992).
C. Helene, "the Anti-Gene Strategy: Control of Gene Expression by Triplex-Forming-Oligonucleotides," 6 Anti-Cancer Drug Design 569-584 (1991).
S. L. Young, S. H. Krawczyk, M. D. Matteucci and J. J. Toole, "Triple Helix Formation Inhibits Transcription Elongation In Vitro," 88 Proc. Natl. Acad. Sci. USA 10023-10026 (1991)
A. S. Moffat, "Triplex DNA Finally Comes of Age," 252 Science 1374-1375 (1991).
M. I. Dawson, A. N. Jina, S. Torkelson, S. Rhee, M. Moore, D. A. Zarling and P. D. Hobbs, "Synthesis and Characterization of a Ribavirin-3',5'-Phosphate Pentadecamer Homoribopolymer Bearing a 5'-Amino Tether Group and a 3'-Thymidine," 18 Nucleic Acids Research 1099-1102 (1990).
S. Pochet and R. D'Ari, "Synthesis and Enzymatic Polymerisation of 5-Amino-1-(2'-Deoxy-.beta.-D-Ribofuranosyl)Imidazole-4-Carboxamide-5'-Trip hosphate," 18 Nucleic Acids Research 7127-7131 (1990).
T. A. Millican, G. A. Mock, M. A. Chauncey, T. P. Patel, M. A. W. Eaton, J. Gunning, S. D. Cutbush, S. Neidle and J. Mann, "Synthesis and Biophysical Studies of Short Oligodeoxynucleotides With Novel Modifications: A Possible Approach to the Problem of Mixed Base Oligodeoxynucleotide Synthesis," 12 Nucleic Acids Research 7435-7453 (1984).
F. Seela and K. Kaiser, "Phosphoramidites of Base-Modified 2'-Deoxyinosine Isosteres and Solid-Phase Synthesis of d(GCI CGC) Oligomers Containing an Ambiguous Base," 14 Nucleic Acids Research 1825-1845 (1986).
P. K. T. Lin and D. M. Brown, "Synthesis and Duplex Stability of Oligonucleotides Containing Cytosine-Thymine Analogues," 17 Nucleic Acids Research 10373-10383 (1989).
P. Francois, D. Perilleux, Y. Kempener and E. Sonveaux, "Flexible Aglycone Residues in Duplex DNA," 31 Tetrahedron Letters 6347-6350 (1990).
J. F. Habener, C. D. Vo, D. B. Le, G. P. Gryan, L. Ercolani and A. H.-J. Wang, "5-Fluorodeoxyuridine as an Alternative to the Synthesis of Mixed Hybridization Probes for the Detection of Specific Gene Sequences," 85 Proc. Natl. Acad. Sci. USA 1735-1739 (1988).
K. Ramasamy, R. K. Robins and G. R. Revankar, "Total Synthesis of 2'-Deoxytoyocamycin, 2'-Deoxysangivamycin and Related 7-.beta.-D-Arabinofuranosylpyrrolo(2,3-d) Pyrimidines Via Ring Closure of Pyrrole Precursors Prepared by the Stereospecific Sodium Salt Glycosylation Procedure," 42 Tetrahedron 5869-5878 (1986).
K. Ramasamy, R. K. Robins and G. R. Revankar, "Synthesis of Brunfelsamidine Ribonucleoside and Certain Related Compounds by the Sterospecific Sodium Salt Glycosylation Procedure," 7(3) Neucleosides & Nucleotides 385-392 (1988).
J. T. Witkowski, M. Fuertes, P. D. Cook and R. K. Robins, "Necleosides of 1,2,4-Triazole-3-Carboxamide: Synthesis of Certain Pentofuranosyl, Deoxypento-furanosyl and Pentopyranosyl 1,2,4-Triazoles," 2(1) Journal of Carbohydrates.cndot.Nucleosides.cndot.Nucleotides 1-36 (1975).
O. Makabe, H. Suzuki and S. Umezawa, "Syntheses of D-Arabinofuranosyl and 2'-Deoxy-D-Ribofuranosyl 1,2,3-Triazolecarboxamides," 50 Bulletin of the Chemical Society of Japan 2689-2693 (1977).
T. Huynh-Dinh and J. Igolen, "Synthesis of C-Nucleosides. Part 14. 5(3)-Glycosyl-1,2,4-Triazole-3(5)-Carboxamides as Analogues of Ribavirin," J. C. S. Perkin I 761-764 (1977).
Abstract 102:77265x, 102 16-Fermentations 469 (1985).
Abstract 84766a, 78 Chemical Abstracts 472 (1973).
Andrews Philip C.
Bergstrom Donald E.
Nichols Ruthann
Zhang Peiming
Lankford L. Blaine
Robinson Douglas W.
LandOfFree
3-nitropyrrole nucleoside does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3-nitropyrrole nucleoside, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-nitropyrrole nucleoside will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-734420