3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivativ

Details 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivativ 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivativ

1997-02-13

1999-01-26

Houtteman, Scott W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 73, 536 74, 536 75, C07H 1708

Patent

active

058640231

ABSTRACT:
The disclosed invention relates to novel 3'-N-O, 9-O-oxime protected, 6-O-alkyl erthyromycin derivatives, a process of preparing the same. The invention also relates to a process of preparing 6-O-alkyl erythromycin A by eliminating the 3'-N-oxide group and 9-O-oxime protecting groups and optionally deprotecting the hydroxy groups at the 2'- and 4"- positions under suitable reaction conditions.

REFERENCES:
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Technical Information, "Methods of Formulating Controlled Release Products Outside of the Claims of Forest Laboratory Patents".
Green, T. H., et al., "Protective Groups in Organic Synthesis", 2nd Edition, John Wiley & Sons, New York, 1991.

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