3-'N-modified 6-O-substituted erythromycin ketolide derivatives

Details 3-'N-modified 6-O-substituted erythromycin ketolide derivatives 3-'N-modified 6-O-substituted erythromycin ketolide derivatives

1998-08-11

2000-03-07

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 72, 536 79, 536 185, A61K 3170, C07H 100, C07H 1708

Patent

active

06034069&

ABSTRACT:
Novel 3'-N-modified 6-O-substituted erythromycin ketolide compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.

REFERENCES:
patent: 5444051 (1995-08-01), Agouridas et al.
Journal of Antibiotics, vol. 43 (1990), pp. 286-294, Morimoto, et al., "Chemical Modification of Erythromycins--II, Synthesis and Antibacterial Activity of O-Alkyl Derivatives of Erythromycin A".
Journal of Pharmaceutical Sciences, vol. 79, No. 9 (Sep. 1989), pp. 783-784, Suwa, et al., "Uptake of O-Alkyl Erythromycin Derivatives in the Lung Tissue and Cells of Rats".
Journal of Antibiotics, vol. 37 (1984), pp. 187-189, Morimoto et al., "Chemical Modification of Erythromycins--I. Synthesis and Antibacterial Activity of 6-O-Methylerythromycins A".

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