3'-modified oligonucleotide derivatives

Details 3'-modified oligonucleotide derivatives 3'-modified oligonucleotide derivatives

1995-06-05

1997-12-09

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 44, 536 231, 536 242, 435 6, C07H 1900, C07H 2102, C12Q 168, A01N 4304

Patent

active

056962487

ABSTRACT:
Novel oligonucleotide analogs of the formulae I and II ##STR1## in which A, B, D, R.sup.1, R.sup.2, T, U, V, W, X, Y, Z, a, b, m, m', n and n' have the meanings stated in the description, with valuable physical, biological and pharmacological properties, and a process for the preparation thereof are described. Application thereof relates to the use as inhibitors of gene expression (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex forming oligonucleotides), as probes for detecting nucleic acids and as aids in molecular biology.

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