3-(Methylsulfinyl)cinnolinones and their derivatives

Details 3-(Methylsulfinyl)cinnolinones and their derivatives 3-(Methylsulfinyl)cinnolinones and their derivatives

1973-11-15

1976-02-10

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260578, C07D23728

Patent

active

039377040

ABSTRACT:
3-substituted cinnolinones having the following structural formula are disclosed: ##SPC1##
Wherein R.sub.1 is hydrogen, lower alkyl, aralkyl or acyl and R.sub.2 and R.sub.3 are hydrogen, halogen, lower alkoxy or lower alkyl, and X is ##EQU1## CH.sub.3 COOCH.sub.2 S-, or ##SPC2##
These compounds are useful as immunosuppressants.

REFERENCES:
patent: 3669965 (1972-01-01), White
Castle, Ed., Heterocyclic Compounds, Vol. 28, "Condensed Pyridazines Including Cinnolines and Phthalazines", Wiley--Interscience, N.Y. 1973, p. 87-91, 64-66, 119-120.
Becher et al. I J. Org. Chem. 28, 1895 (1963).
Becher et al. II J. Org. Chem. 28, 1896.
Becher et al. III J. Amer. Chem. Soc. 85, 3410(1963).
Ockenden, et al., J. Chem. Society 1953, 3706-3707.

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