3-Methyleneazetidine derivatives

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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260239A, C07D20508, A61K 31395

Patent

active

042606063

ABSTRACT:
This invention provides a novel class of 3-methyleneazetidines which include diphenylmethyl derivatives such as 1-isopropyl-3-diphenylmethyleneazetidine oxalate: ##STR1## This illustrated 3-methyleneazetidine compound is characterized by a combination of pharmacological properties which are indicative of utility as a mood elevating therapeutic agent for relieving the symptoms of depression in humans. The illustrated compound exhibits an ED.sub.50 (tetrabenazine-induced ptosis) of 2.18 mg/kg in mice.

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Morimoto et al., Chem. Abst. 78, 135964y, (1973).

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