3-methylamino-1-(2-thienyl)-1-propanone, production and use...

Details 3-methylamino-1-(2-thienyl)-1-propanone, production and use... 3-methylamino-1-(2-thienyl)-1-propanone, production and use...

2007-08-21

2007-08-21

Anderson, Rebecca (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S074000

Reexamination Certificate

active

10542003

ABSTRACT:
The present invention relates to the preparation of 3-methylamino-1-(2-thienyl)-1-propanone and its use for preparing the pharmaceutical (+)-(S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate—(trade name Duloxetine®).

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Wheeler, W. J. et al., “An Asymmetric Synthesis Of Duloxetine Hydrochloride, A Mixed Uptake Inhibitor Of Serotonin And Norepinephrine, And Its C-14 Labeled Isotopomers”, Journal of Labelled Compounds and Radiopharmaceuticals, 36 (3) (1995), pp. 213-223.

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