3-[methyl or dimethyl)amino]-6-(pyridinyl)pyridazines and their

Details 3-[methyl or dimethyl)amino]-6-(pyridinyl)pyridazines and their 3-[methyl or dimethyl)amino]-6-(pyridinyl)pyridazines and their

1981-10-05

1986-05-20

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544238, A61K 3144, C07D21384, C07D21374

Patent

active

045901945

ABSTRACT:
3-(NB)-4-Q-6-PY-pyridazines (I) or salts thereof, which are useful as cardiotonics, are prepared by reacting a 3-halo-4-Q-6-PY-pyridazine with an amine, H-NB, to produce I, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents and Q is cyano when NB is NHCH.sub.3 or N(CH.sub.3).sub.2, or Q is carbamyl when NB is NHCH.sub.3, or Q is hydrogen when NB is N(CH.sub.3).sub.2. Cardiotonic use of said 3-(NB)-4-Q-6-PY-pyridazines or salts is shown.

REFERENCES:
patent: 3462432 (1969-08-01), Gall et al.
patent: 4011220 (1977-03-01), Kropp et al.
patent: 4072746 (1978-02-01), Lesher et al.
patent: 4251658 (1981-02-01), Szilagyl et al.
patent: 4304775 (1981-12-01), Lesher et al.
patent: 4313951 (1982-02-01), Lesher et al.
Haginiwa et al., [Yakugaku Zasshi, 98 (1), 67-71 (1978); Chem. Abstrs. 88, 170,096v (1978)].
Cheesman et al, "Basicity of Pyridazine Derivatives", J. Chem. Soc., Perkins Trans. 2 (1972), pp. 392-394.

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