3-<4-substituted-4-piperazinyl)buty]-4-thiazolidinone and rel

Details 3-<4-substituted-4-piperazinyl)buty]-4-thiazolidinone and rel 3-<4-substituted-4-piperazinyl)buty]-4-thiazolidinone and rel

1993-06-29

1994-12-06

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514253, 514254, 544230, 544295, 544364, 544363, 544368, 544369, 548146, A61K 31495, A61K 3150, C07D40300, C07D40100

Patent

active

053710878

ABSTRACT:
There are disclosed compounds of the formula, ##STR1## where n is 0, 1 or 2; A is ##STR2## where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; Y in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino cyano, trifluoromethyl or methylthio; m is 1 or 2; k is 1 or 2; R.sub.1 and R.sub.2 are independently hydrogen, loweralkyl, ##STR3## or aryl except that when R.sub.1 is ##STR4## or aryl, R.sub.2 is hydrogen, or alternatively R.sub.1 +R.sub.2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, indan or piperidine ring; R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl, or alternatively R.sub.3 +R.sub.4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl signifying an unsubstituted phenyl group or a phenyl group substituted with 1, 2 or 3 substituents each of which being independently loweralkyl, loweralkoxy, hydroxy, halogen, loweralkylthio, cyano, amino or trifluoromethyl, which are useful as antipsychotic, analgesic, anticonvulsant and anxiolytic agents.

REFERENCES:
patent: 4933453 (1990-06-01), Hrib et al.
patent: 5037984 (1991-08-01), Hrib et al.
patent: 5041445 (1991-08-01), Hrib et al.
March, Advanced Organic Chemistry, 3rd Edition, 1985, p. 1089.
Biochemical Organic Compounds for Research and Diagnostic Reagents, Sigma Chemical Company, (1994) p. 857.

Affiliated with

Also associated with

Rating

3-<4-substituted-4-piperazinyl)buty]-4-thiazolidinone and rel does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-<4-substituted-4-piperazinyl)buty]-4-thiazolidinone and rel, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-<4-substituted-4-piperazinyl)buty]-4-thiazolidinone and rel will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-214653