3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514339, 546201, 5462774, A61K 31445, C07D40104

Patent

active

055211976

ABSTRACT:
This invention provides novel 5-HT.sub.1F agonists which are useful for the treatment of migraine and associated disorders having the following formula: ##STR1## wherein A, B, X, Y, Ar and n are defined in the specification.

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Friderichs et al. "Serotonin derivatives with cyclic side chains . . . " CA 84:4794u (1976).
Guillaume et al. "Synthesis of 3-(1,2,3,6-tetrahydropyridin-4-yl) 1H-indole" CA 107:70255p (1987).
Back et al. "Synthese von 2- und 3-(1,2,3,6-Tetrahydropyridyl)-indolen" Helv. Chim. Acta vol. 51 pp. 260-265 (1968).

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